The Santini family bought the villa from the Buonvisi family in 1651.
The building in its present form is the result of modifications carried out before 1710, which was realized on a construction in the second half of the 17th century. The person responsible for the restructuring project of the façade was the Bolognese architect Torregiani. Interior modifications and decoration follow immediately after the work carried out on the façade. Research carried out by Marcello Fagiolo and Maria Adriani Giusti on the original layout of the park, found that Bernardo Raggi and Giovanni Lazzoni among others, worked on it during a period that runs from 1673 to 1686. The strong French influence in its realisation is explained by the fact that Nicolao Santini, owner of the villa, was the Republic of Lucca ambassador to the court of King Sole. In the early 1800's, elements from the romantic period were added to the garden, complying with the fashion of the English garden. Nevertheless, the substantial characteristics of the relationship between the garden and the building were not subverted.